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When gut bacteria ferment fiber, they produce butyrate, propionate, and acetate which stimulate GLP-1 release from L-cells through the receptors FFAR2 (GPR43) and FFAR3 (GPR41)
7 If an SGLT-2 inhibitor cannot be taken due to a contraindication to therapy, drug intolerance, or insufficient kidney function, the ADA recommends the addition of a GLP-1 RA ( Figure 2 )
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Depending on individual needs, healthcare professionals may recommend combining it with Folic Acid , Iron , Vitamin D , Calcium , or other nutritional supplements
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